2,2,2-Trifluoro-1-(3-morpholin-4-yl-phenyl)-ethanone oxime → 2,2,2-Trifluoro-1-(3-morpholin-4-yl-phenyl)-ethylamine
반응식
[F:1][C:2]([F:19])([F:18])[C:3]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH:7]=1)=[N:4]O>[OH-].[NH4+].CO.[Ni]>[F:19][C:2]([F:1])([F:18])[CH:3]([NH2:4])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH:7]=1참가 물질
5
실험 절차
A suspension of 2,2,2-trifluoro-1-(3-morpholin-4-yl-phenyl)-ethanone oxime (1.37 g) and Ra—Ni (1 mL) in a mixture of 3 ml of 30% ammonium hydroxide and 15 mL of MeOH was hydrogenated at 60 psi for 16 hours. The crude reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo to give the title compound as an oil (1.3 g).
후처리
- customThe crude reaction mixture
- filtrationwas filtered through Celite
- concentrationthe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-06c65228e5d74afb96402c67f1390346
- 출처 데이터셋
- uspto-grants-2004_12
- 특허 번호
- US06831080B2
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