Hydrochloric Acid → 6-Bromo-3-hydroxyquinoline-4-carboxylic acid
반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=O)[C:5]2=[O:12].[OH-].[K+].BrC[C:17](=O)[C:18]([OH:20])=[O:19].Cl>O>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]=[CH:6][C:5]([OH:12])=[C:17]2[C:18]([OH:20])=[O:19]참가 물질
6
실험 절차
A solution of 5-bromoisatin (2.26 g, 10 mmol) and potassium hydroxide (4.48 g, 80 mmol) in water (10 mL) was warmed until the materials were dissolved then cooled to room temperature, treated with bromopyruvic acid (2.3 g, 14 mmol), stirred for 6 days, adjusted to pH <7 with concentrated HCl, and filtered. The solid was washed with water and ethanol and dried to provide the desired product (1.5 g, 58%). MS (DCI/NH3) m/e 269 (M+H)+.
후처리
- dissolutionwere dissolved
- filtrationfiltered
- washThe solid was washed with water and ethanol
- customdried
출처 및 근거
- ORD 기록
- ord-3f7e934123bc4bbd848614d0d557abb7
- 출처 데이터셋
- uspto-grants-2004_12
- 특허 번호
- US06831175B2
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