Phosphorus oxychloride → 4,7-Dichloropyrido[2,3-d]pyrimidine

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:10](O)=[N:9][CH:8]=[N:7][C:6]=2[N:12]=1.P(Cl)(Cl)([Cl:15])=O>>[Cl:15][C:10]1[C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[N:12][C:6]=2[N:7]=[CH:8][N:9]=1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 178518043HCID 178518043, 화합물

생성물 1

HCID 226077594,7-Dichloropyrido[2,3-d]pyrimidine수율 73%

실험 절차

A mixture of Example 140C (1 g, 5.5 mmol) in phosphorus oxychloride (40 mL) was refluxed for 2 h then cooled and evaporated. The residue was taken into ethyl acetate (75 ml), washed with saturated sodium bicarbonate (50 ml) water (50 ml) and brine (50 ml). The ethyl acetate was evaporated to yield 0.8 g of product (73%).

후처리

temperaturethen cooled
customevaporated
washwashed with saturated sodium bicarbonate (50 ml) water (50 ml) and brine (50 ml)
customThe ethyl acetate was evaporated

출처 및 근거

ORD 기록: ord-2b7a77ded1d942b688d3a870805edb11
출처 데이터셋: uspto-grants-2004_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06831175B2

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