Triethylamine → Ethyl oxo-[N'-(3-phenylpropionyl)hydrazino]acetate

HRID 230789

반응식

HRID 230789 반응식
[C:1]1([CH2:7][CH2:8][C:9]([NH:11][NH2:12])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.Cl[C:21](=[O:27])[C:22]([O:24][CH2:25][CH3:26])=[O:23]>C(Cl)(Cl)Cl>[O:27]=[C:21]([NH:12][NH:11][C:9](=[O:10])[CH2:8][CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:22]([O:24][CH2:25][CH3:26])=[O:23]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 20884Ethoxalyl chlorideHCID 2493483-Phenylpropanehydrazide

생성물 1

HCID 68997631Ethyl oxo-[N'-(3-phenylpropionyl)hydrazino]acetate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

The 3-phenylpropionic acid hydrazide mixture (499 mg) obtained in Production Example 22-1 was dissolved in chloroform (30 mL), and triethylamine (0.86 mL) and ethyl chloroglyoxalate (0.4 mL) were added thereto, and stirred at room temperature for 5 hours. After the reaction, the reaction liquid was entirely concentrated, and the resulting residue was purified through silica gel column chromatography (chloroform/methanol=94/6) to obtain the entitled compound (760 mg).

후처리

  1. customAfter the reaction
  2. customthe reaction liquid
  3. concentrationwas entirely concentrated
  4. customthe resulting residue was purified through silica gel column chromatography (chloroform/methanol=94/6)

출처 및 근거

ORD 기록
ord-6feddf2aa9af48918ff794a2e92064c8
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07566781B2

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