Hydrochloric Acid → 2,4,6-Trimethyl-5-hydroxypyrimidine

HRID 2308138노트

반응식

HRID 2308138 반응식
[CH3:1][C:2]1[O:3][C:4]([C:8](=O)[CH3:9])=[C:5]([CH3:7])[N:6]=1.[OH-].[NH4+:12].Cl>>[CH3:1][C:2]1[N:12]=[C:8]([CH3:9])[C:4]([OH:3])=[C:5]([CH3:7])[N:6]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 3184185-Acetyl-2,4-dimethyloxazole

생성물 1

HCID 1305522,4,6-Trimethyl-5-hydroxypyrimidine수율 60%

실험 절차

The 2,4-dimethyl-5-acetyloxazole is poured into a Parr Bomb with 20 ml (51 mmol) of concentrated ammonium hydroxide and brought to 180° C. in three hours. Heating is continued for 10 hours, and after cooling the mixture is brought to pH 5 with HCl, extracted into ether, dried over Na2SO4 and stripped in vacuo. The residual solid is crystallized from benzene to give pale yellow crystals (1.3 g, 60%).

후처리

  1. temperatureHeating
  2. waitis continued for 10 hours
  3. temperatureafter cooling the mixture
  4. extractionextracted into ether
  5. dry with materialdried over Na2SO4
  6. customThe residual solid is crystallized from benzene

출처 및 근거

ORD 기록
ord-615019f15eda40c49d72965078351c7b
출처 데이터셋
uspto-grants-2004_12
특허 번호
US06835216B2

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