Diphenyl Ether → Ethyl 6-iodo-4-oxo-1,4-dihydro-3-quinolinecarboxylate
반응식
C1(OC2C=CC=CC=2)C=CC=CC=1.[I:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][CH:22]=[C:23]([C:29]([O:31]CC)=O)[C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:17][CH:16]=1>CC(CCC)C>[I:14][C:15]1[CH:16]=[C:17]2[C:18](=[CH:19][CH:20]=1)[NH:21][CH:22]=[C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:29]2=[O:31]참가 물질
4
실험 절차
Diphenyl ether (175 ml) was heated to reflux temperature, and Intermediate 10 was gradually added down an air condenser. Once all the reagent had been added the mixture was heated under reflux for a further 30 min. The mixture was then cooled and 2-methylpentane (200 ml) was added. The solid formed was collected by filtration to give the title compound (24.6 g).
후처리
- additionwas gradually added down an air condenser
- additionOnce all the reagent had been added the mixture
- temperaturewas heated
- temperatureunder reflux for a further 30 min
- temperatureThe mixture was then cooled
- customThe solid formed
- filtrationwas collected by filtration
출처 및 근거
- ORD 기록
- ord-54a385256a874b199dd6d9b03ea3d8d9
- 출처 데이터셋
- uspto-grants-2009_07
- 특허 번호
- US07566786B2
반응 노트
불러오는 중…