N-(5-Chloro-3-methylidene-2,3-dihydro-1-benzofuran-4-yl)-2,2,2-trifluoroacetamide → 2,2,2-Trifluoro-N-(3-methyl-2,3-dihydro-1-benzofuran-4-yl)acetamide

HRID 230848

반응식

HRID 230848 반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][C:7](=[CH2:10])[C:6]=2[C:11]=1[NH:12][C:13](=[O:18])[C:14]([F:17])([F:16])[F:15]>C(O)C.[Pd]>[F:17][C:14]([F:15])([F:16])[C:13]([NH:12][C:11]1[C:6]2[CH:7]([CH3:10])[CH2:8][O:9][C:5]=2[CH:4]=[CH:3][CH:2]=1)=[O:18]

참가 물질

4

반응물 1

HCID 57763270N-(5-Chloro-3-methylidene-2,3-dihydro-1-benzofuran-4-yl)-2,2,2-trifluoroacetamide

생성물 1

HCID 577632852,2,2-Trifluoro-N-(3-methyl-2,3-dihydro-1-benzofuran-4-yl)acetamide수율 104.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of Intermediate 23 (0.10 g) in ethanol (20 ml) was added to 10% palladium on carbon (0.20 g) and the mixture stirred under an atmosphere of hydrogen for 20 h. The mixture was filtered through ‘hyflo’ filter aid, washed with ethanol and the solvent removed in vacuo to give the title compound as a white solid (0.092 g).

후처리

  1. filtrationThe mixture was filtered through ‘hyflo’
  2. filtrationfilter aid
  3. washwashed with ethanol
  4. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-07a50bda887847c5a08ffd5d164601dd
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07566786B2

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