Water → 1-[2-(Benzyloxy)-6-hydroxyphenyl]ethan-1-one

HRID 230869

반응식

HRID 230869 반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[O:11])[CH3:10].C(=O)([O-])[O-].[K+].[K+].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.O>CC(C)=O>[CH2:18]([O:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[O:11])[CH3:10])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 696872',6'-Dihydroxyacetophenone

생성물 1

HCID 27751871-[2-(Benzyloxy)-6-hydroxyphenyl]ethan-1-one

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a mixture of 2′,6′-dihydroxyacetophenone (4 g) and potassium carbonate (3.82 g) in acetone (40 mL) was added benzyl bromide (3.13 mL), and the mixture was stirred at room temperature overnight. The reaction mixture was poured into water, and the precipitated crystals were collected by filtration. The crystals were washed with water and n-hexane, and dried under reduced pressure to give the title compound (3.67 g).

후처리

  1. filtrationthe precipitated crystals were collected by filtration
  2. washThe crystals were washed with water and n-hexane
  3. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-ad510b46ab0447c5abe0f9bfcbc6058e
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07566699B2

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