Hydrogen Bromide → HCID 20186414, 화합물

반응식

C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:15][CH2:14][C:13]3[CH:12]=[N:11][NH:10][C:9]=3[C:7]=2[CH:8]=1.Br.C(=O)(O)[O-].[Na+]>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[S:15][CH2:14][C:13]3[CH:12]=[N:11][NH:10][C:9]=3[C:7]=2[CH:8]=1

참가 물질

반응물 3

HCID 260Hydrogen Bromide

HCID 516892Sodium Bicarbonate

HCID 20186429HCID 20186429, 화합물

생성물 1

HCID 20186414HCID 20186414, 화합물수율 74.9%

실험 절차

A mixture of 8-methoxy-1,4-dihydro[1]benzothiopyrano[4,3-c]pyrazole (6.75 g) and 47% hydrobromic acid (70.2 ml) was refluxed for 3 hours with stirring and allowed to cool to room temperature. The resulting precipitate was collected by filtration and recrystallized from water to give the salt, which was treated with aqueous sodium bicarbonate to give 8-hydroxy-1,4dihydro[1]benzothiopyrano[4,3-c]pyrazole (4.73 g).