Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2-Hydroxyethyl)piperazine → 2-[4-[(4-Methylsulfanylphenyl)methyl]piperazin-1-yl]ethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-(Chloromethyl)-4-(methylthio)benzene | HCID 70128 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-[4-[(4-Methylsulfanylphenyl)methyl]piperazin-1-yl]ethanol | HCID 2057597 | 71.6% |
반응 단계
A mixture of 4-(methylthio)benzyl chloride (28.6 g), 1-(2-hydroxyethyl)piperazine (21.6 g), triethylamine (16.8 g), and ethanol (250 ml) is stirred at room temperature for 5 hours. The ethanol is then removed in vacuo and water added to the residue. The product is extracted with ether, dried, and the ether evaporated to give 31.6 g of 1-(2-hydroxyethyl)-4-[4-(methylthio)benzyl] piperazine as an orange oil, suitable for use in the next reaction.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04692448 |
| 출처 데이터셋 | uspto-grants-1987_09 |
| ORD ID | ord-5e33a732aad4425ba516fd9cf0aaad75 |
| 출처 메모 | uspto-grants-1987_09 |