1-(2-Hydroxyethyl)piperazine → 2-[4-[(4-Methylsulfanylphenyl)methyl]piperazin-1-yl]ethanol

HRID 2309032노트

반응식

HRID 2309032 반응식
[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7]Cl)=[CH:5][CH:4]=1.[OH:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(N(CC)CC)C>C(O)C>[OH:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][N:17]([CH2:7][C:6]2[CH:9]=[CH:10][C:3]([S:2][CH3:1])=[CH:4][CH:5]=2)[CH2:16][CH2:15]1

참가 물질

5

반응물 3

HCID 76771-(2-Hydroxyethyl)piperazineHCID 8471TriethylamineHCID 701281-(Chloromethyl)-4-(methylthio)benzene

생성물 1

HCID 20575972-[4-[(4-Methylsulfanylphenyl)methyl]piperazin-1-yl]ethanol수율 71.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 4-(methylthio)benzyl chloride (28.6 g), 1-(2-hydroxyethyl)piperazine (21.6 g), triethylamine (16.8 g), and ethanol (250 ml) is stirred at room temperature for 5 hours. The ethanol is then removed in vacuo and water added to the residue. The product is extracted with ether, dried, and the ether evaporated to give 31.6 g of 1-(2-hydroxyethyl)-4-[4-(methylthio)benzyl] piperazine as an orange oil, suitable for use in the next reaction.

후처리

  1. customThe ethanol is then removed in vacuo and water
  2. additionadded to the residue
  3. extractionThe product is extracted with ether
  4. customdried
  5. customthe ether evaporated

출처 및 근거

ORD 기록
ord-5e33a732aad4425ba516fd9cf0aaad75
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04692448

반응 노트

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