Hydrochloric Acid → 3-[2-(4-Aminophenyl)ethyl]-4-hydroxybenzofuran

HRID 230908노트

반응식

HRID 230908 반응식
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][C:13]2[C:17]3[C:18]([OH:22])=[CH:19][CH:20]=[CH:21][C:16]=3[O:15][CH:14]=2)=[CH:7][CH:6]=1)(=O)C.Cl.C(=O)([O-])O.[Na+]>C(O)CC>[NH2:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][CH2:12][C:13]2[C:17]3[C:18]([OH:22])=[CH:19][CH:20]=[CH:21][C:16]=3[O:15][CH:14]=2)=[CH:9][CH:10]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 671358873-[2-(4-Acetylaminophenyl)ethyl]-4-hydroxybenzofuran

생성물 1

HCID 671360293-[2-(4-Aminophenyl)ethyl]-4-hydroxybenzofuran수율 49.6%

시약·촉매·용매 1

HCID 10311-Propanol용매

실험 절차

A mixture of 3-[2-(4-acetylaminophenyl)ethyl]-4-hydroxybenzofuran (1.2 g) and n-propanol (4 mL)-5 mol/L aqueous sodium hydroxide solution (8 mL) was heated for ref lux overnight. The reaction mixture was cooled to room temperature. To the reaction mixture was added 2 mol/L hydrochloric acid (21 mL). The mixture was poured into a saturated aqueous sodium hydrogen carbonate solution, and the resulting mixture was extracted with ethylacetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, and the residue was treated with ethyl acetate. The precipitated crystals were collected by filtration and dried under reduced pressure to give the title compound (0.51 g).

후처리

  1. temperaturewas heated for ref lux overnight
  2. extractionthe resulting mixture was extracted with ethylacetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvent was removed under reduced pressure
  6. additionthe residue was treated with ethyl acetate
  7. filtrationThe precipitated crystals were collected by filtration
  8. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-5bd16d54df774310a1d614d5cc883302
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07566699B2

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