Thiourea → Ethyl 5-[[(amino)(imino)methyl]thiomethyl]-1,3-dimethyl-1H-pyrazole-4-carboxylate
반응식
Cl[CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([CH3:9])[C:4]=1[C:10]([O:12][CH2:13][CH3:14])=[O:11].[NH2:15][C:16]([NH2:18])=[S:17]>C(O)C>[NH2:18][C:16](=[NH:15])[S:17][CH2:2][C:3]1[N:7]([CH3:8])[N:6]=[C:5]([CH3:9])[C:4]=1[C:10]([O:12][CH2:13][CH3:14])=[O:11]참가 물질
4
실험 절차
A solution under nitrogen was prepared from 10.7 g of the compound produced in Example 1 and 3.95 g of thiourea in 200 ml of ethanol. After refluxing the solution four hours, it was allowed to stir at room temperature overnight. The solvent was removed under reduced pressure. Then, the residue was triturated with hexane to give 16 g of solid (wet weight), m.p. 175°-180° C.
후처리
- temperatureAfter refluxing the solution four hours, it
- customThe solvent was removed under reduced pressure
- customThen, the residue was triturated with hexane
출처 및 근거
- ORD 기록
- ord-8191ab3a5ff14d5691f5f2b69f790fb2
- 출처 데이터셋
- uspto-grants-1987_09
- 특허 번호
- US04693743
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