HCID 20186023, 화합물 → HCID 20186009, 화합물

HRID 2309192노트

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HRID 2309192 반응식
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:30]=[CH:31][CH:32]=2)[O:11][CH2:12][CH2:13][CH2:14][C:15]2[NH:20][C:19](=[O:21])[C:18]([O:22]CC3C=CC=CC=3)=[CH:17][N:16]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:30]=[CH:31][CH:32]=2)[O:11][CH2:12][CH2:13][CH2:14][C:15]2[NH:20][C:19](=[O:21])[C:18]([OH:22])=[CH:17][N:16]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

3

반응물 1

HCID 20186023HCID 20186023, 화합물

생성물 1

HCID 20186009HCID 20186009, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

2-[3-[3-(Piperidinomethyl)phenoxy]propyl]-5-benzyloxypyrimidin-4-one (0.68 g) was stirred under reduced pressure and taken to pH 8 with hours in lN hydrochloric acid (20 ml). The mixture was concentrated under reduced pressure and taken to pH 8 with aqueous sodium bicarbonate. This mixture was extracted with n-butanol (3×20 ml); these extracts were combined, washed with water (2'5 ml), dried (MgSO4) and evaporated under reduced pressure to give the title compound. This was dissolved in methanol containing ethanolic HCl, excess solvent was evaporated under reduced pressure and the residue crystallised from isopropanol-acetone to give 2-[3-[3-(piperidinomethyl)phenoxy]propyl]-5-hydroxypyrimidin -4-one dihydrochloride (0.24 g), m.p. 192°-4° C.

후처리

  1. concentrationThe mixture was concentrated under reduced pressure
  2. extractionThis mixture was extracted with n-butanol (3×20 ml)
  3. washwashed with water (2'5 ml),
  4. dry with materialdried (MgSO4)
  5. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-24b85461beab4b6a9fbd6be26f0676f3
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04694008

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