Glyoxylic Acid → Trans 4-(2,5-dimethyl-3-furyl)-4-oxo-2-butenoic Acid
반응식
[C:1]([C:4]1[CH:8]=[C:7]([CH3:9])[O:6][C:5]=1[CH3:10])(=[O:3])[CH3:2].[C:11]([OH:15])(=[O:14])[CH:12]=O>O>[CH3:10][C:5]1[O:6][C:7]([CH3:9])=[CH:8][C:4]=1[C:1](=[O:3])/[CH:2]=[CH:12]/[C:11]([OH:15])=[O:14]참가 물질
4
실험 절차
As in Example 1, one starts out with 9 g of 3-acetyl 2.5-dimethylfuran (J. Am. Chem. Soc., 70 739 (1948)), 6 g glyoxylic acid and 6 cm3 water. Following chromatography on silica (eluent: petroleum ether-ethyl acetate (2-8), recrystallization in ethyl acetate, 1.8 g of the expected product is obtained. MP=144°-147° C.
후처리
- custompetroleum ether-ethyl acetate (2-8), recrystallization in ethyl acetate
출처 및 근거
- ORD 기록
- ord-7053e5b61ed6406cbd5d0791d2f73b7d
- 출처 데이터셋
- uspto-grants-1987_09
- 특허 번호
- US04694019
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