Hydrochloric Acid → 2-[(4-chlorophenyl)formamido]-3-(1H-indol-3-yl)propanoic acid

HRID 2309235노트

반응식

HRID 2309235 반응식
[NH2:1][CH:2]([C:13]([OH:15])=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](Cl)=[O:28])=[CH:25][CH:24]=1.Cl>CC(C)=O.O>[Cl:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([NH:1][CH:2]([CH2:3][C:4]2[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[NH:6][CH:5]=2)[C:13]([OH:15])=[O:14])=[O:28])=[CH:25][CH:24]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 1148Dl-TryptophanHCID 85014-Chlorobenzoyl chlorideHCID 11430Potassium Carbonate

생성물 1

HCID 27875262-[(4-chlorophenyl)formamido]-3-(1H-indol-3-yl)propanoic acid

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매2회

실험 절차

10 Grams of DL-tryptophane was dissolved in a mixture of 100 ml of acetone with 20 ml of water, then to this solution was added 6 g of potassium carbonate. Under an ice-cooled condition, 9 g of 4-chlorobenzoyl chloride was added dropwise to the above-mentioned mixture, and the reaction mixture was stirred at the same temperature for 2 hours. Then, acetone was removed by evaporation, to the residue thus obtained was added water, and mixture was acidified by adding concentrated hydrochloric acid, the crystals formed were collected by filtration, and washed with water. Recrystallized from ethanol to obtain 14 g of 2-(4-chlorobenzoylamino)-3-(indol-3-yl)propionic acid. White powdery substance.

후처리

  1. additionwas added dropwise to the above-mentioned mixture
  2. customThen, acetone was removed by evaporation, to the residue
  3. customthus obtained
  4. customthe crystals formed
  5. filtrationwere collected by filtration
  6. washwashed with water
  7. customRecrystallized from ethanol

출처 및 근거

ORD 기록
ord-424afda66e394569ac6515d23402e828
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04694017

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