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Dimethyl Sulfoxide → 4-[p-(2-Cyanoethyl)phenyl]pentylcyclohexane

HRID 2309287
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인쇄 미리보기

반응식

HRID 2309287 반응식
Cl[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:20])[CH2:11][CH2:12][CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:6][CH:5]=1.CS(C)=O.[C-:25]#[N:26].[Na+].Cl[O-].[Na+]>O>[C:25]([CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:20])[CH2:11][CH2:12][CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:6][CH:5]=1)#[N:26]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 8929Sodium CyanideHCID 201862644-[p-(2-Chloroethyl)phenyl]pentylcyclohexaneHCID 23665760Sodium Hypochlorite

생성물 1

HCID 201862634-[p-(2-Cyanoethyl)phenyl]pentylcyclohexane

시약·촉매·용매 1

HCID 962Water용매

실험 절차

9 Grams of the 4-[p-(2-chloroethyl)phenyl]pentylcyclohexane, 100 ml of dimethyl sulfoxide ((CH3)2SO) and 23 g of sodium cyanide (NaCN) were stirred together at 140° to 150° C. for 2 hours. After the resulting mixture was cooled, a 10% aqueous sodium hypochlorite (NaClO) solution was added. Further, water was added thereto, and the precipitate was recrystallized from ligroin to obtain 4-[p-(2-cyanoethyl)phenyl]pentylcyclohexane. The melting point of this compound was 44° to 46° C.

후처리

  1. temperatureAfter the resulting mixture was cooled
  2. customthe precipitate was recrystallized from ligroin

출처 및 근거

ORD 기록
ord-61da5bc4ea0f469096927aedc166b160
출처 데이터셋
uspto-grants-1987_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04694098

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