Diazomethane → Methyl 7-(2-oxocyclopentyl)heptanoate

HRID 2309559노트

반응식

HRID 2309559 반응식
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14].[N+](=[CH2:18])=[N-]>CCOCC>[CH3:18][O:14][C:13](=[O:15])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH:3]1[CH2:4][CH2:5][CH2:6][C:2]1=[O:1]

참가 물질

4

반응물 2

HCID 9550DiazomethaneHCID 989472-Oxocyclopentaneheptanoic acid

생성물 1

HCID 13099223Methyl 7-(2-oxocyclopentyl)heptanoate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A 2.14 g. portion of 7-(2-oxocyclopentyl)-heptanoic acid was dissolved in 20 ml. of anhydrous ether and cooled to 0° C. in an ice bath. The stirred solution was then treated with ethereal diazomethane in about 1 ml. portions to control gas evolution until the yellow color persisted and bubbling was slow. The excess reagent was then blown off with a stream of nitrogen and the solvent evaporated at the rotovap. The residual oily ester was dried in vacuo over phosphorous pentoxide.

후처리

  1. custombubbling
  2. customthe solvent evaporated at the rotovap
  3. dry with materialThe residual oily ester was dried in vacuo over phosphorous pentoxide

출처 및 근거

ORD 기록
ord-3f7f559b05714d5a81aa4dcef06c6133
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04695647

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