Methyl Isocyanate → HCID 20184542, 화합물

HRID 2309908노트

반응식

HRID 2309908 반응식
[NH2:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([O:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][C:10]=3[O:20][CH3:21])[NH:8][C:4]=2[CH:3]=1.[CH3:24][N:25]=[C:26]=[O:27]>O1CCCC1>[CH3:24][NH:25][C:26]([NH:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([O:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][C:10]=3[O:20][CH3:21])[NH:8][C:4]=2[CH:3]=1)=[O:27]

참가 물질

4

반응물 2

HCID 12228Methyl IsocyanateHCID 20184521HCID 20184521, 화합물

생성물 1

HCID 20184542HCID 20184542, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

One gram (3.0 mmol) of 5-amino-2-(2'-methoxy-4'-methanesulfonyloxy-phenyl)-benzimidazole was dissolved in 30 ml of pure tetrahydrofuran, 2.0 ml of methylisocyanate were added, and the mixture was refluxed. After 15 minutes that solvent and any excess methylisocyanate were evaporated off in vacuo, and the residue obtained was chromatographed over 250 gm of aluminium oxide (neutral) (eluant: methylene chloride with 4% ethanol).

후처리

  1. temperaturethe mixture was refluxed
  2. customany excess methylisocyanate were evaporated off in vacuo
  3. customthe residue obtained
  4. customwas chromatographed over 250 gm of aluminium oxide (neutral) (eluant: methylene chloride with 4% ethanol)

출처 및 근거

ORD 기록
ord-e84a37f80ced475c85ed29204c29fd8a
출처 데이터셋
uspto-grants-1987_09
특허 번호
US04696931

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