Hydrochloric Acid → (4,6-Dimethylpyrimidin-2-yl)cyanamide
반응식
[C:1]([NH:3][C:4]([NH2:6])=[NH:5])#[N:2].[CH3:7][C:8](=O)[CH2:9][C:10](=O)[CH3:11].Cl>O>[C:1]([NH:3][C:4]1[N:6]=[C:10]([CH3:11])[CH:9]=[C:8]([CH3:7])[N:5]=1)#[N:2]참가 물질
5
반응 조건
- 온도
- 120 °C
실험 절차
A mixture of 42 g (0.5 mol) of cyanoguanidine ("dicyanodiamide") and 50 g (0.5 mol) of 2,4-pentanedione ("acetylacetone") is heated to 120° C. for 15 hours. The reaction mixture is then cooled, after which 500 ml of water are added and the solution is acidified with hydrochloric acid at 0° C. to 10° C. The product obtained in crystalline form during this procedure is isolated by filtering it off under suction. 51.8 g (70% of theory) of 2-cyanoamino-4,6-dimethyl-pyrimidine of melting point 205° C. are obtained.
후처리
- temperatureThe reaction mixture is then cooled
- customThe product obtained in crystalline form during this procedure
- customis isolated
- filtrationby filtering it off under suction
출처 및 근거
- ORD 기록
- ord-51595aaaff7745dbb35de9db42182aa9
- 출처 데이터셋
- uspto-grants-1989_07
- 특허 번호
- US04844730
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