Hydrochloric Acid → HCID 178492595, 화합물

HRID 231030노트

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HRID 231030 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[N:11]=[C:12]=[S:13].[N-:14]=[N+:15]=[N-:16].[Na+].O.Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[N:11]1[C:12]([SH:13])=[N:16][N:15]=[N:14]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 33557Sodium AzideHCID 1424662,5-Dimethoxyphenyl isothiocyanate

생성물 1

HCID 178492595HCID 178492595, 화합물수율 75%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2,5-Dimethoxyphenylisothiocyanate (39 g, 0.22 mol) and sodium azide (14.3 g, 0.22 mol) were added to a mixture of water (150 ml) and ethanol (60 ml) and the mixture was heated on a steam bath to about 80° C. to 90° C. with stirring for 3 hours. The reaction mixture was cooled to room temperature and a 2N HCl solution (100 ml) was added. The raw crystals formed were collected by filtration and recrystallized from isopropanol to obtain 1-(2,5-dimethoxyphenyl)-5-mercaptotetrazole (35.7 g, yield 75%). The melting point was 151° to 152° C.

후처리

  1. temperaturethe mixture was heated on a steam bath to about 80° C. to 90° C.
  2. customThe raw crystals formed
  3. filtrationwere collected by filtration
  4. customrecrystallized from isopropanol

출처 및 근거

ORD 기록
ord-e4af83f098bc41be8d9e0a820e79d5e8
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04845020

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