Water → N-([(4-Bromophenyl)amino]carbonyl)-4-methoxybenzenesulfonamide

HRID 231135

반응식

HRID 231135 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH2:12])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[OH-].[Na+].[Br:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]=[C:23]=[O:24])=[CH:18][CH:17]=1.O>CC(C)=O>[Br:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23]([NH:12][S:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)(=[O:11])=[O:10])=[O:24])=[CH:18][CH:17]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 707894-MethoxybenzenesulfonamideHCID 756094-Bromophenyl isocyanate

생성물 1

HCID 14480021N-([(4-Bromophenyl)amino]carbonyl)-4-methoxybenzenesulfonamide수율 91.9%

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

To a solution of 9.97 g of 4-methoxybenzenesulfonamide in 54 ml of acetone were added 54 ml of a 1N sodium hydroxide solution. With stirring, a solution of 11.55 g of 4-bromophenylisocyanate in 50 ml of acetone was added. After stirring at room temperature for three days, the reaction mixture was filtered and 55 ml of 1N hydrochloric acid were added to the filtrate providing a fine white precipitate. Two hundred milliliters of water were added, and the solid was recovered by filtration to provide 18.85 g of the desired title product.

후처리

  1. stirringAfter stirring at room temperature for three days
  2. filtrationthe reaction mixture was filtered
  3. addition55 ml of 1N hydrochloric acid were added to the filtrate
  4. customproviding a fine white precipitate
  5. filtrationthe solid was recovered by filtration

출처 및 근거

ORD 기록
ord-c4993c3210e545c4affc8802d81baeb4
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04845128

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