Thionyl Chloride → HCID 14501734, 화합물

HRID 231398노트

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HRID 231398 반응식
[F:1][C:2]([F:10])([F:9])[CH2:3][O:4][CH2:5][C:6](O)=[O:7].S(Cl)([Cl:13])=O>C(Cl)(Cl)Cl>[F:1][C:2]([F:10])([F:9])[CH2:3][O:4][CH2:5][C:6]([Cl:13])=[O:7]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 4738453(2,2,2-trifluoroethoxy)acetic acid

생성물 1

HCID 14501734HCID 14501734, 화합물수율 54.6%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a 3-neck 500 ml round-bottom flask equipped with a magnetic stirrer, reflux condenser and addition funnel was added (2,2,2-trifluoroethoxy)acetic acid (30.90 g, 0.196 moles) and 250 ml of chloroform under nitrogen. Thionyl chloride (30.20 g, 0.250 moles) was added dropwise and the solution refluxed for 2 hours. The mixture was then concentrated by distillation of the chloroform and excess thionyl chloride. The remaining yellow oil was distilled in vacuo to give 18.9 g of the product as a colorless oil, bp 40°-48° C./20 mm.

후처리

  1. customTo a 3-neck 500 ml round-bottom flask equipped with a magnetic stirrer
  2. temperaturereflux
  3. additioncondenser and addition funnel
  4. temperaturethe solution refluxed for 2 hours
  5. concentrationThe mixture was then concentrated by distillation of the chloroform and excess thionyl chloride
  6. distillationThe remaining yellow oil was distilled in vacuo

출처 및 근거

ORD 기록
ord-40681304b10842c7b07f9c5deebeebed
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04846873

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