2-Chloro-4-fluoro-5-nitrotoluene → 4-Chloro-2-fluoro-5-methylaniline

HRID 231407

반응식

HRID 231407 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([N+:9]([O-])=O)=[CH:4][C:3]=1[CH3:12].[H][H]>C(O)(=O)C.[Pt]>[Cl:1][C:2]1[C:3]([CH3:12])=[CH:4][C:5]([NH2:9])=[C:6]([F:8])[CH:7]=1

참가 물질

5

반응물 2

HCID 101039792-Chloro-4-fluoro-5-nitrotolueneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 141574954-Chloro-2-fluoro-5-methylaniline

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 176Acetic Acid용매

실험 절차

A solution of 2-chloro-4-fluoro-5-nitrotoluene (30.0 g, 0.158 mole) in glacial acetic acid (150 ml) was added to a 250 ml Parr bottle which contained platinum IV oxide (0.4 g). The Parr bottle was placed on a Parr hydrogenation apparatus and charged with hydrogen. The reaction mixture was allowed to shake until hydrogen absorption ceased. The catalyst was removed by vacuum filtration. The filtrate containing 4-chloro-2-fluoro-5-methylaniline was used in the following step. This reaction was repeated several times.

후처리

  1. customto shake until hydrogen absorption
  2. customThe catalyst was removed by vacuum filtration
  3. additionThe filtrate containing 4-chloro-2-fluoro-5-methylaniline

출처 및 근거

ORD 기록
ord-9b0c3425db194681af283128da57f87f
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04846875

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