N-bromobutanimide → 2-Bromo-1-(bromomethyl)-4-fluorobenzene

HRID 231446노트

반응식

HRID 231446 반응식
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH3:9].[Br:10]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][Br:10]

참가 물질

5

반응물 2

HCID 67184N-bromobutanimideHCID 740162-Bromo-4-fluorotoluene

생성물 1

HCID 107069772-Bromo-1-(bromomethyl)-4-fluorobenzene수율 100.6%

시약·촉매·용매 2

HCID 7187Benzoyl Peroxide촉매HCID 5943Carbon Tetrachloride용매

실험 절차

By the method of Example 7, Step C, 75 g (0.40 mole) of 2-bromo-4-fluorotoluene, 70.6 g (0.40 mole) of N-bromosuccinimide, and 2.5 g (0.03 mole) of benzoyl peroxide were reacted in 450 ml of carbon tetrachloride, yielding 107.8 g of impure 2-bromo-4-fluorobenzyl bromide (68% assay).

출처 및 근거

ORD 기록
ord-cd61df16fa9a4f7da91b0735c126bb45
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04846882

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