Water → Ethyl 1-isopentyl-4-nitro-1H-pyrrole-2-carboxylate

HRID 23146

반응식

HRID 23146 반응식
[CH2:1]([O:3][C:4]([C:6]1[NH:7][CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)=[O:5])[CH3:2].[O-]CC.[Na+].Br[CH2:19][CH2:20][CH:21]([CH3:23])[CH3:22].O>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH2:19][CH2:20][CH:21]([CH3:23])[CH3:22])[CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)=[O:5])[CH3:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 78911-Bromo-3-methylbutaneHCID 242169Ethyl 4-Nitropyrrole-2-carboxylateHCID 2723922Sodium ethoxide

생성물 1

HCID 67183320Ethyl 1-isopentyl-4-nitro-1H-pyrrole-2-carboxylate수율 29%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

4-Nitro-1H-pyrrole-2-carboxylic acid ethyl ester (3.69 g, 20.04 mmol) was dissolved in 100 ml of hot anhydrous ethanol and the solution was cooled to room temperature. 30 ml of sodium ethoxide (about 1M) in ethanol was added. The reaction mixture was stirred at room temperature for 20 min and 1-bromo-3-methylbutane (8 ml) was added. The mixture was stirred at reflux for 6 h and cooled to room temperature and then poured into water. The pale yellow precipitates were collected by filtration, washed with water, and dried to give the product (1.48 g, 29%).

후처리

  1. stirringThe mixture was stirred
  2. temperatureat reflux for 6 h
  3. temperaturecooled to room temperature
  4. customThe pale yellow precipitates
  5. filtrationwere collected by filtration
  6. washwashed with water
  7. customdried

출처 및 근거

ORD 기록
ord-69759c971e2e427683be49f0c87c3811
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849713B2

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