Ethanone, 1-(2,5-dichlorophenyl)- → 2',5'-Dichloro-3-dimethylaminoacrylophenone

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:11])[CH:10]=[CH:14][N:15]([CH3:17])[CH3:16]

참가 물질

반응물 2

HCID 75587Ethanone, 1-(2,5-dichlorophenyl)-

HCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 28062062',5'-Dichloro-3-dimethylaminoacrylophenone

실험 절차

A mixture of 31.0 g of 2',5'-dichloroacetophenone and 25 ml of N,N-dimethylformamide dimethyl acetal was heated on a steam bath for 6 hours, then evaporated to dryness in vacuo. The residue was slurried with hexane, filtered, and gave 35.3 g of 2',5'-dichloro-3-dimethylaminoacrylophenone as orange crystals, mp 83°-85° C.

후처리

temperaturewas heated on a steam bath for 6 hours
customevaporated to dryness in vacuo
filtrationfiltered

출처 및 근거

ORD 기록: ord-27d59ec2fd5b4cf2ac7c6f2167b13832
출처 데이터셋: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04847256

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