Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2',5'-Dichloro-3-dimethylaminoacrylophenone → 7-(2,5-Dichlorophenyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2',5'-Dichloro-3-dimethylaminoacrylophenone | HCID 2806206 | — |
| 반응물 | HCID 178510443 | HCID 178510443 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 7-(2,5-Dichlorophenyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 14501874 | 92.5% |
반응 단계
A mixture of 98.3 g of 2',5'-dichloro-3-dimethylaminoacrylophenone and 43.5 g of 3-aminopyrazole-4-carbonitrile in one liter of glacial acetic acid was heated at reflux for 63/4 hours. The reaction mixture was cooled and diluted with water to provide a precipitate which was collected, washed with water and dried in vacuo to give 107.6 g of 7-(2,5-dichlorophenyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile as pale yellow crystals, mp 202°-204° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04847256 |
| 출처 데이터셋 | uspto-grants-1989_07 |
| ORD ID | ord-436e2c460fc44074b5d41b95bacf20f0 |
| 출처 메모 | uspto-grants-1989_07 |