Bromine → 3-Bromo-5-chloropyridin-2-amine

HRID 231531

반응식

HRID 231531 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[Br:9]Br>C(Cl)Cl>[NH2:1][C:2]1[C:7]([Br:9])=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 661742-Amino-5-chloropyridine

생성물 1

HCID 27639713-Bromo-5-chloropyridin-2-amine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

20 g (77.8 mmol) of 2-amino-5-chloropyridine dissolved in 160 ml of CH2Cl2 are reacted with 8 ml of bromine, which is added dropwise at 0° C. After the addition is complete, the mixture is left to react at 25° C. for 2 h. The suspension is washed with 10% strength sodium hydroxide solution, and the organic phase is washed with water and then dried over MgSO4, filtered and evaporated. The compound obtained is recrystallized in isopropanol. M.p. 82° C.

후처리

  1. additionis added dropwise at 0° C
  2. additionAfter the addition
  3. waitthe mixture is left
  4. customto react at 25° C. for 2 h
  5. washThe suspension is washed with 10% strength sodium hydroxide solution
  6. washthe organic phase is washed with water
  7. dry with materialdried over MgSO4
  8. filtrationfiltered
  9. customevaporated
  10. customThe compound obtained
  11. customis recrystallized in isopropanol

출처 및 근거

ORD 기록
ord-3451f38d55ba4813800da4d87e3bf5b8
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04847263

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