p-Chlorophenacyl bromide → 8-Bromo-6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine

HRID 231532

반응식

HRID 231532 반응식
[NH2:1][C:2]1[C:7]([Br:8])=[CH:6][C:5]([Cl:9])=[CH:4][N:3]=1.Br[CH2:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=1)=O.C(=O)([O-])O.[Na+]>C(O)C>[Br:8][C:7]1[C:2]2[N:3]([CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)[N:1]=2)[CH:4]=[C:5]([Cl:9])[CH:6]=1

참가 물질

5

반응물 3

HCID 68303p-Chlorophenacyl bromideHCID 516892Sodium BicarbonateHCID 27639713-Bromo-5-chloropyridin-2-amine

생성물 1

HCID 142349178-Bromo-6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

17 g (82 mmol) of 2-amino-3-bromo-5-chloropyridine dissolved in 150 ml of ethanol are reacted with 29 g of 2-bromo-1-(4-chlorophenyl)-1-ethanone and 14 g of sodium hydrogen carbonate. The mixture is brought to the refluxing temperature for 6 h and cooled. The precipitate is filtered off and rinsed with CH2Cl2, and the filtrate is concentrated under reduced pressure. After recrystallization of the evaporation residue in ethyl acetate, the compound melts at 178° C.

후처리

  1. temperaturecooled
  2. filtrationThe precipitate is filtered off
  3. washrinsed with CH2Cl2
  4. concentrationthe filtrate is concentrated under reduced pressure
  5. customAfter recrystallization of the evaporation residue in ethyl acetate

출처 및 근거

ORD 기록
ord-8a2f27f02afd4b7b85817dfa22b20cfb
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04847263

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