Water → 2-Amino-4-phenylthiazole

HRID 231546노트

반응식

HRID 231546 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[NH2:11][C:12]([NH2:14])=[S:13].O>CO>[NH2:14][C:12]1[S:13][CH:2]=[C:3]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:11]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6259Phenacyl bromideHCID 2723790Thiourea

생성물 1

HCID 403022-Amino-4-phenylthiazole수율 85.15%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 19.9 g (0.10 mol) of α-bromo-acetophenone and 11.4 g (0.15 mol) of thiourea in 75 ml of methanol is refluxed for 2 h. It is evaporated to dryness under reduced pressure and the evaporation residue is taken up with water. The resulting solution, heated to the reflux temperature, is treated with CXA charcoal and then rendered alkaline with aqueous ammonia. The precipitate formed is isolated by filtration and purified by recrystallization from isopropanol, with CXA charcoal treatment. to give 15 g (yield: 85.15%) of the expected product in the form of water-insoluble white needles. M.p. (inst.)=150° C.

후처리

  1. customIt is evaporated to dryness under reduced pressure
  2. temperatureThe resulting solution, heated to the reflux temperature
  3. additionis treated with CXA charcoal
  4. customThe precipitate formed
  5. customis isolated by filtration
  6. custompurified by recrystallization from isopropanol, with CXA charcoal treatment

출처 및 근거

ORD 기록
ord-c7e2722c24ed4f17a5955e331ecbdc30
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04847274

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