HCID 13740041, 화합물 → (1-Chlorocyclopropyl)(4-fluorophenyl)methanone
반응식
[Cl:1][CH:2]([C:6]([C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1)=[O:7])[CH2:3][CH2:4]Cl>C(O)(C)(C)C>[F:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]([C:2]2([Cl:1])[CH2:4][CH2:3]2)=[O:7])=[CH:9][CH:10]=1참가 물질
3
반응 조건
- 온도
- 40 °C
실험 절차
233 g (0.99 mol) of 4-fluorophenyl 1,3-dichloropropyl ketone are dissolved in 300 ml of tert.-butanol and 135 g of potassium tert.-butylate are added in portions. The mixture is substantially stirred at 40° C. for 2 hours and concentrated in vacuo. The residue is taken up in methylene chloride and water. The organic phase is seperated off, dried over sodium sulphate and concentrated in vacuo. The residue is distilled under a high vacuum. 145 g (74% of theory) of 1-(4-fluorobenzoyl)-1-chloro-cyclopropane of boiling point 73° C./0.1 mbar are obtained.
후처리
- concentrationconcentrated in vacuo
- customThe organic phase is seperated off
- dry with materialdried over sodium sulphate
- concentrationconcentrated in vacuo
- distillationThe residue is distilled under a high vacuum
출처 및 근거
- ORD 기록
- ord-bc79fda6a8934fb5a58439b21f02e166
- 출처 데이터셋
- uspto-grants-1989_07
- 특허 번호
- US04847279
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