Sodium Iodide → 3-Iodomethyl-1-(4-fluorophenyl)-pyrrolidine-2,5-dione

HRID 231560

반응식

HRID 231560 반응식
Cl[CH2:2][CH:3]1[CH2:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[C:4]1=[O:16].[I-:17].[Na+]>CC(C)=O>[I:17][CH2:2][CH:3]1[CH2:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[C:4]1=[O:16]

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 200334793-Chloromethyl-1-(4-fluorophenyl)-pyrrolidine-2,5-dione

생성물 1

HCID 200335443-Iodomethyl-1-(4-fluorophenyl)-pyrrolidine-2,5-dione수율 92%

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

A solution of 15.2 g (0.06 moles) 3-chloromethyl-1-(4-fluorophenyl)-pyrrolidine-2,5-dione (according to Example 1) and 10.7 g (0.066 moles) sodium iodide in acetone were refluxed for 8 hours in acetone. The precipitated sodium chloride was then filtered off, and the filtrate was concentrated, extracted with chloroform and the extract once more concentrated. The desired product was obtained in a yield of 92%. Melting point: 156° C.

후처리

  1. filtrationThe precipitated sodium chloride was then filtered off
  2. concentrationthe filtrate was concentrated
  3. extractionextracted with chloroform
  4. extractionthe extract once more
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-24dd3ef3458d4214aa2f8d4a0a3fc612
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04847285

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