Xanthine → 8-Benzylamino-1,3-di-n-butyl-xanthine

HRID 231626

반응식

Br[C:2]1[NH:10][C:9]2[C:8](=[O:11])[N:7]([CH2:12][CH2:13][CH2:14][CH3:15])[C:6](=[O:16])[N:5]([CH2:17][CH2:18][CH2:19][CH3:20])[C:4]=2[N:3]=1.[CH2:21]([NH2:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.N1C(=O)C2NC=NC=2NC1=O>>[CH2:21]([NH:28][C:2]1[NH:10][C:9]2[C:8](=[O:11])[N:7]([CH2:12][CH2:13][CH2:14][CH3:15])[C:6](=[O:16])[N:5]([CH2:17][CH2:18][CH2:19][CH3:20])[C:4]=2[N:3]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

반응물 3

HCID 1188Xanthine

HCID 7504Benzylamine

HCID 101544891,3-Di-n-butyl-8-bromo Xanthine

생성물 1

HCID 136218088-Benzylamino-1,3-di-n-butyl-xanthine

실험 절차

Heat together a mixture of one equivalent of 8-bromo-1,3-di-n-butyl-xanthine and three to four equivalents of benzylamine at 160°-180° C. until thin layer chromatography shows that no starting xanthine remains. Cool. Triturate with ethanol and water to yield 8-benzylamino-1,3-di-n-butyl-xanthine.

후처리

temperatureHeat together
temperatureCool
customTriturate with ethanol and water

출처 및 근거

ORD 기록: ord-6d22cc9235084e6093c36040f24c1394
출처 데이터셋: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04847377

연결된 노트

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