3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester → Methyl 4-aminothiophene-3-carboxylate Hydrochloride

HRID 231641

반응식

HRID 231641 반응식
O=[C:2]1[CH2:6][S:5][CH2:4][CH:3]1[C:7]([O:9][CH3:10])=[O:8].[ClH:11].[NH2:12]O>C(#N)C>[ClH:11].[NH2:12][C:2]1[C:3]([C:7]([O:9][CH3:10])=[O:8])=[CH:4][S:5][CH:6]=1

참가 물질

4

반응물 2

HCID 984243-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl esterHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 2777609Methyl 4-aminothiophene-3-carboxylate Hydrochloride수율 77.4%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

4-Oxo-3-methoxycarbonyltetrahydrothiophene (3.9 g) was heated under reflux for 1 hour with hydroxylamine hydrochloride (2 g) in acetonitrile 10 ml). The mixture was then cooled and the solid portion was filtered off and washed with dry diethyl ether to afford the title compound (3.65 g), m.p. 203°-204° C.

후처리

  1. temperatureThe mixture was then cooled
  2. filtrationthe solid portion was filtered off
  3. washwashed with dry diethyl ether

출처 및 근거

ORD 기록
ord-ee69670acd5843ca96cce8c411cf44b0
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04847386

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