Potassium Hydroxide → HCID 20033693, 화합물

HRID 231679

반응식

HRID 231679 반응식
[SH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[OH-].[K+].Br[C:15]1[S:19][C:18]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:17][CH:16]=1>CN(C)C=O.O>[C:9]([CH2:8][C:5]1[CH:4]=[CH:3][C:2]([S:1][C:15]2[S:19][C:18]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:17][CH:16]=2)=[CH:7][CH:6]=1)([OH:11])=[O:10]

참가 물질

6

반응물 3

HCID 14797Potassium HydroxideHCID 12413045-Bromo-2-thiophenesulfonamideHCID 33905114-Mercaptophenylacetic acid

생성물 1

HCID 20033693HCID 20033693, 화합물

시약·촉매·용매 2

HCID 962Water용매2회HCID 6228Dimethylformamide용매2회

반응 조건

온도
120 °C

실험 절차

4-Mercaptophenylacetic acid (2.3 g) was dissolved in dimethylformamide under a nitrogen atmosphere and 1.8 g of potassium hydroxide dissolved in a minimum amount of water was added. 5-bromothiophene-2-sulfonamide (3.3 g) dissolved in dimethylformamide was added and the mixture heated at 120° C. for 2 hours. After cooling to room temperature water was added to the reaction mixture, the pH was adjusted to 8.6 and the mixture was extracted with ethyl acetate. The aqueous phase was separated and acidified, causing a solid to precipitate. The solid was collected by filtration and dried under vacuum to a weight of 3.25 g.

후처리

  1. additionwas added
  2. additionwas added
  3. additionwas added to the reaction mixture
  4. extractionthe mixture was extracted with ethyl acetate
  5. customThe aqueous phase was separated
  6. customto precipitate
  7. filtrationThe solid was collected by filtration
  8. customdried under vacuum to a weight of 3.25 g

출처 및 근거

ORD 기록
ord-e9ec0aeb8d5c4266906869950d3ea639
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04847289

연결된 노트

불러오는 중…