Methanol → Pyrimidine, 4-(1H-imidazol-1-yl)-6-methoxy-

반응식

Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)[CH:3]=1.[Na].[CH3:14][OH:15]>>[N:8]1([C:4]2[CH:3]=[C:2]([O:15][CH3:14])[N:7]=[CH:6][N:5]=2)[CH:12]=[CH:11][N:10]=[CH:9]1

참가 물질

반응물 3

HCID 887Methanol

HCID 27576124-Chloro-6-(1H-imidazol-1-yl)pyrimidine

HCID 5360545Sodium

생성물 1

HCID 3087488Pyrimidine, 4-(1H-imidazol-1-yl)-6-methoxy-

실험 절차

Following the procedure of Example 15, 180 mg of 6-chloro-4-(1-imidazolyl)pyrimidine was reacted with 23 mg of sodium metal and 2 ml of anhydrous methanol to yield 136 mg 4-(1-imidazolyl)-6-methoxypyrimidine, having a melting point of 152°-153° C., recrystallized from a mixture of n-hexane and ethyl acetate.

출처 및 근거

ORD 기록: ord-0256f64bed2545eea9ed40cf1037b7e3
출처 데이터셋: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04849424

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