Water → 2-[(Oxiran-2-yl)methoxy]anthracene-9,10-dione

HRID 231911

반응식

HRID 231911 반응식
[OH:1][C:2]1[CH:15]=[CH:14][C:13]2[C:12](=[O:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5](=[O:17])[C:4]=2[CH:3]=1.[H-].[Na+].[CH2:20]([CH:22]1[O:24][CH2:23]1)Cl.O>CN1CCCC1=O>[CH2:20]([O:1][C:2]1[CH:15]=[CH:14][C:13]2[C:12](=[O:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5](=[O:17])[C:4]=2[CH:3]=1)[CH:22]1[O:24][CH2:23]1

참가 물질

6

반응물 4

HCID 962WaterHCID 7835EpichlorohydrinHCID 117962-HydroxyanthraquinoneHCID 24758Sodium hydride

생성물 1

HCID 134236012-[(Oxiran-2-yl)methoxy]anthracene-9,10-dione수율 50.57%

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
0 °C

실험 절차

112.1 g (0.5 mole) of 2-hydroxyanthraquinone are dissolved in 500 ml of N-methylpyrrolidone, and 12 g (0.5 mole) of sodium hydride are added in portions. When the evolution of gas has ended, 46.37 ml (0.5 mole) of epichlorohydrin are added dropwise at 70° C. and stirring is continued at 70° C. for a further 8 hours. 1.5 liters of water are then added, the mixture is filtered and the filter cake is dried in vacuo. After drying, the product is boiled up again in 1 liter of N,N-dimethylformamide with 10 g of active charcoal and filtered hot. The crystals which precipitate on cooling to 0° C. are separated off by filtration and dried under a high vacuum. 69.45 g (50.57% of theory) of 2-anthraquinonyl glycidyl ether are obtained;

후처리

  1. filtrationthe mixture is filtered
  2. customthe filter cake is dried in vacuo
  3. customAfter drying
  4. filtrationfiltered hot
  5. customThe crystals which precipitate
  6. customare separated off by filtration
  7. customdried under a high vacuum

출처 및 근거

ORD 기록
ord-c5fe9765ef3445faa73491c8e34e0c63
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04849533

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