Acetic Acid → N2 [(1,1-Dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysine, ethyl ester

HRID 231946

반응식

HRID 231946 반응식
N#N.[CH3:3][C:4]([CH3:29])([O:6][C:7]([NH:9][C@H:10]([C:26]([OH:28])=[O:27])[CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17])=[O:8])[CH3:5].[N+:30](=C)=[N-:31].[C:33](O)(=O)[CH3:34].N#N.CC(C)(OC(N[C@H](C(OC)=O)CCCCNC(OCC1C=CC=CC=1)=O)=O)C>C(OCC)(=O)C.CC(C)=O.CCCCCC>[N:30]#[N:31].[CH3:5][C:4]([CH3:29])([O:6][C:7]([NH:9][C@H:10]([C:26]([O:28][CH2:33][CH3:34])=[O:27])[CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]([O:18][CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:17])=[O:8])[CH3:3]

참가 물질

8

반응물 4

HCID 176Acetic AcidHCID 9550DiazomethaneHCID 86742311N2 [(1,1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysineHCID 131714291N2 [(1,1-Dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysine, methyl ester

생성물 1

HCID 131716012N2 [(1,1-Dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysine, ethyl ester

시약·촉매·용매 3

HCID 180Acetone용매HCID 8058Hexane용매HCID 8857Ethyl Acetate용매

실험 절차

N2 -[(1,1-Dimethylethoxy)carbonyl]-N6 -[(phenylmethoxy)carbonyl]-L-lysine (5.48 g., 14.4 mmole) is dissolved in ethyl acetate (130 ml.). Diazomethane is added until a yellow color persists. Acetic acid is added to quench the excess diazomethane, and the volatiles are evaporated. The residue is partitioned between ethyl acetate and saturated sodium bicarbonate, the organic layer is dried over sodium sulfate, filtered, and then the volatiles are evaporated. Purification of the residue by column chromatography on LPS-1 silica eluting with 30% ethyl acetate/hexane yields 4.0 g. of N2 -[(1,1-dimethylethoxy)carbonyl]-N6 -[(phenylmethoxy)carbonyl]-L-lysine, methyl ester. TLC (silica gel; hexane:acetone, 1:1) Rf =0.69.

후처리

  1. customto quench the excess diazomethane
  2. customthe volatiles are evaporated
  3. customThe residue is partitioned between ethyl acetate and saturated sodium bicarbonate
  4. dry with materialthe organic layer is dried over sodium sulfate
  5. filtrationfiltered
  6. customthe volatiles are evaporated
  7. customPurification of the residue by column chromatography on LPS-1 silica eluting with 30% ethyl acetate/hexane
  8. customyields 4.0 g

출처 및 근거

ORD 기록
ord-21245ab6dfb242aea21b6a51d4edb4cb
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04849414

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