2,3-Dihydroxybutanedioic Acid → HCID 178424608, 화합물

HRID 232022

반응식

HRID 232022 반응식
[N:1]1([CH2:7][C:8]2[CH:9]=[N:10][N:11]([O:13][CH2:14][CH2:15][CH2:16][NH2:17])[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CS[C:20]1[NH:21][CH:22]=[C:23]([CH2:27][C:28]2[CH:29]=[CH:30][C:31]([CH3:34])=[N:32][CH:33]=2)[C:24](=[O:26])[N:25]=1.C(O)(=O)C(C(C(O)=O)O)O>N1C=CC=CC=1.C(O)(C)C>[N:1]1([CH2:7][C:8]2[CH:9]=[N:10][N:11]([O:13][CH2:14][CH2:15][CH2:16][NH:17][C:20]3[NH:21][CH:22]=[C:23]([CH2:27][C:28]4[CH:29]=[CH:30][C:31]([CH3:34])=[N:32][CH:33]=4)[C:24](=[O:26])[N:25]=3)[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

6

반응물 3

HCID 8752,3-Dihydroxybutanedioic AcidHCID 138232143-(4-Piperidinomethylpyrazol-1-yloxy)propylamineHCID 178503537HCID 178503537, 화합물

생성물 1

HCID 178424608HCID 178424608, 화합물

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 3776Isopropanol용매

실험 절차

3.5 g of 3-(4-piperidinomethylpyrazol-1-yloxy)propylamine and 3.6 g of 2-methylthio-5-(2-methylpyrid-5-ylmethyl)-1H-pyrimid-4-one in 30 ml of pyridine are refluxed for 30 hours. The pyridine is distilled off and the residue is then chromatographed over neutral Al2O3 (activity level III) using methylene chloride/3% strength methanol as the mobile phase. The oil obtained is reacted with tartaric acid in isopropanol to give an amorphous solid.

후처리

  1. distillationThe pyridine is distilled off
  2. customthe residue is then chromatographed over neutral Al2O3 (activity level III)
  3. customThe oil obtained
  4. customto give an amorphous solid

출처 및 근거

ORD 기록
ord-e8522393088a431c8f6a3da6b41f6ee4
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851410

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