18-Crown-6 → 4-(6-Hydroxyhexyloxy)-4'-nitrobiphenyl

HRID 232186

반응식

HRID 232186 반응식
[K].[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.I[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][OH:25].C1OCCOCCOCCOCCOCCOC1>C1(C)C=CC=CC=1>[OH:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[CH:7][CH:8]=1

참가 물질

6

반응물 4

HCID 2855718-Crown-6HCID 1380784-Hydroxy-4'-nitrobiphenylHCID 5462222Potassium2회HCID 130890816-Iodo-1-hexanol

생성물 1

HCID 197795694-(6-Hydroxyhexyloxy)-4'-nitrobiphenyl

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To 500 ml of toluene in a one liter round bottom flask, fitted with a condenser and magnetic stirrer, are added 7.6 g (0.03M) of the potassium salt of 4-hydroxy-4'-nitrobiphenyl, 4.9 g (0.035M) of 6-iodo-1-hexanol, and 0.5 g of 18-crown-6ether. The mixture is refluxed for about 20 hours until all of the potassium salt has dissolved and reacted as evidenced by the absence of the blue crystalline solid. The solution is filtered hot, and then cooled to room temperature. After solvent removal, the solid residue is recrystallized from ethanol to yield a purified product, m.p. 117°-119° C.

후처리

  1. dissolutionhas dissolved
  2. customreacted
  3. filtrationThe solution is filtered hot
  4. customAfter solvent removal
  5. customthe solid residue is recrystallized from ethanol
  6. customto yield a purified product, m.p. 117°-119° C.

출처 및 근거

ORD 기록
ord-504722cb99994f9ebfc8e18c90c1158c
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851502

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