1,6-Dibromohexane → 4-(6-Bromohexyloxy)-4'-nitrobiphenyl

HRID 232189

반응식

HRID 232189 반응식
[K].[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[Br:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]Br.C1OCCOCCOCCOCCOCCOC1>C1(C)C=CC=CC=1>[Br:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[CH:7][CH:8]=1

참가 물질

6

반응물 4

HCID 123681,6-DibromohexaneHCID 2855718-Crown-6HCID 1380784-Hydroxy-4'-nitrobiphenylHCID 5462222Potassium

생성물 1

HCID 200312344-(6-Bromohexyloxy)-4'-nitrobiphenyl

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To 500 ml of toluene in a 100 ml round bottom flask, fitted with a condenser and magnetic stirrer, are added 7.6 g (0.03M) of the potassium salt of 4-hydroxy-4'-nitrobiphenyl, 36.6 g (0.15M) of 1,6-dibromohexane, and 0.5 g of 18-crown-6 ether. The mixture is refluxed for about 20 hours, and then filtered hot. The solvent is evaporated, and the residual crude product is recrystallized from hexane to provide purified product.

후처리

  1. temperatureThe mixture is refluxed for about 20 hours
  2. filtrationfiltered hot
  3. customThe solvent is evaporated
  4. customthe residual crude product is recrystallized from hexane
  5. customto provide
  6. custompurified product

출처 및 근거

ORD 기록
ord-461c4c42d3ed4873a93c3b353d018e40
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851502

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