Thionyl Chloride → HCID 20030930, 화합물

HRID 232231노트

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HRID 232231 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[O:24])[C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)=[O:12])([OH:3])=O.S(Cl)([Cl:27])=O>ClC(Cl)C>[Cl:27][C:10]1([C:11]([O:13][CH2:14][C:15]2[CH:16]=[CH:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=2)=[O:12])[C:5]2[C:4](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:1](=[O:3])[O:24]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 86743267HCID 86743267, 화합물

생성물 1

HCID 20030930HCID 20030930, 화합물

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

실험 절차

In 15 ml of dichloroethane was dissolved 580 mg of Compound (97), followed by addition of 0.58 ml of thionyl chloride. The mixture was heated for one hour under reflux. The solvent was evaporated off, and the residue was treated with isopropylether to give 500 mg of the subject Compound (98) as colorless crystals, m.p. 132°-134° C.

후처리

  1. temperatureThe mixture was heated for one hour
  2. temperatureunder reflux
  3. customThe solvent was evaporated off
  4. additionthe residue was treated with isopropylether

출처 및 근거

ORD 기록
ord-89123cdad9c847ea8d5509cddc926a77
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851422

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