Tetrahydrofuran → HCID 20031369, 화합물

HRID 232258노트

반응식

HRID 232258 반응식
O1CCCC1.[CH2:6]([N:11]1[CH2:16][CH2:15][N:14]([C:17]([CH:19]2[CH2:21][CH:20]2[C:22](O)=[O:23])=O)[CH2:13][CH2:12]1)[CH2:7][CH2:8][CH2:9][CH3:10].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O>[CH2:6]([N:11]1[CH2:12][CH2:13][N:14]([CH2:17][CH:19]2[CH2:21][CH:20]2[CH2:22][OH:23])[CH2:15][CH2:16]1)[CH2:7][CH2:8][CH2:9][CH3:10]

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 20031396HCID 20031396, 화합물HCID 21226445Aluminium lithium hydride

생성물 1

HCID 20031369HCID 20031369, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

To 100 mL of tetrahydrofuran is added 24.0 g (0.1 mol) of 2-[(4-pentylpiperazin-1-yl)carbonyl]cyclopropanecarboxylic acid and 13.6 g (0.4 mol) of lithium aluminum hydride. Reflux the reaction and monitor by thin-layer chromatography. Upon completion add 14 mL of H2O, 14 mL of 15% aqueous NaOH, and 42 mL of H2O. Remove the precipitate by suction filtration through celite and remove the solvent in vacuo to obtain the title compound.

후처리

  1. temperatureReflux
  2. customthe reaction and monitor by thin-layer chromatography
  3. customRemove the precipitate
  4. filtrationby suction filtration through celite
  5. customremove the solvent in vacuo

출처 및 근거

ORD 기록
ord-de1f78178e17401c8a8424ca6e05eeea
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851526

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