Hydrochloric Acid → HCID 20031401, 화합물

HRID 232288노트

반응식

HRID 232288 반응식
[C-:1]#[N:2].[Na+].CS(O[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[N:15]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=O)=O.Cl>CCOCC>[C:17]1([CH2:16][N:15]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:10]2[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]2[C:1]#[N:2])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8929Sodium CyanideHCID 54076726HCID 54076726, 화합물

생성물 1

HCID 20031401HCID 20031401, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To 100 mL of ether is added 10 g (0.2 mol) of sodium cyanide and 37.3 g (0.1 mol) of 2-[bis(phenylmethyl)amino]-cyclohexanol methanesulfonate. Reflux the reaction and monitor by thin-layer chromatography. Upon completion add 1N HCl until gas evolution ceases. Remove the solvent in vacuo and add saturated aqueous sodium bicarbonate and 100 mL methylene chloride. Dry the organic phase over Na2SO4. Filter off the drying agent and evaporate the solvent in vacuo to obtain the title compound.

후처리

  1. temperatureReflux
  2. customthe reaction and monitor by thin-layer chromatography
  3. customRemove the solvent in vacuo
  4. additionadd saturated aqueous sodium bicarbonate and 100 mL methylene chloride
  5. dry with materialDry the organic phase over Na2SO4
  6. filtrationFilter off the drying agent
  7. customevaporate the solvent in vacuo

출처 및 근거

ORD 기록
ord-d0921dfb842043d7a1000c1c1daa5375
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851526

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