P-Cresol → N-[2-(4-Methylphenoxy)ethyl]acetamide

HRID 232311

반응식

HRID 232311 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH3:9][C:10]1[O:11][CH2:12][CH2:13][N:14]=1>C(Cl)Cl>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:12][CH2:13][NH:14][C:10](=[O:11])[CH3:9])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 2879P-CresolHCID 707132-Methyl-2-oxazoline

생성물 1

HCID 538338N-[2-(4-Methylphenoxy)ethyl]acetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Combine 5.0 g (0.046 mol) 4-methylphenol and 3.9 g (0.46 mol) 2-methyl-2-oxazoline under a nitrogen atmosphere and heat to 175° C. for 18 hours. After this time, cool the reaction mixture and add 50 mL of methylene chloride. Wash the organics with 3×10 mL of 10% potassium hydroxide, dry over sodium sulfate and remove the solvents to obtain the title compound.

후처리

  1. temperatureAfter this time, cool the reaction mixture
  2. washWash the organics with 3×10 mL of 10% potassium hydroxide
  3. dry with materialdry over sodium sulfate
  4. customremove the solvents

출처 및 근거

ORD 기록
ord-7c51a4b7facc43c296c5d45e86fa81e8
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851526

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