N-[2-(4-Methylphenoxy)ethyl]acetamide → N-Ethyl-2-(4-methylphenoxy)ethanamine

HRID 232312

반응식

HRID 232312 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][C:8]1[CH:20]=[CH:19][C:11]([O:12][CH2:13][CH2:14][NH:15][C:16](=O)[CH3:17])=[CH:10][CH:9]=1>CCOCC>[CH2:16]([NH:15][CH2:14][CH2:13][O:12][C:11]1[CH:10]=[CH:9][C:8]([CH3:7])=[CH:20][CH:19]=1)[CH3:17]

참가 물질

4

반응물 2

HCID 538338N-[2-(4-Methylphenoxy)ethyl]acetamideHCID 21226445Aluminium lithium hydride

생성물 1

HCID 20031351N-Ethyl-2-(4-methylphenoxy)ethanamine

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a chilled suspension of 0.49 g (013 mol) lithium aluminium hydride in 50 mL anhydrous ether, add 5.0 g (025 mol) N-[2-(4-methylphenoxy)ethyl]acetamide at a rate which maintains the reaction temperature below 10° C. Allow to warm to room temperature and stir at ambient temp. for 24 hrs. After this time, quench the mixture with H2O and filter the salts. Concentrate the filtrate to obtain the title compound.

후처리

  1. customthe reaction temperature below 10° C
  2. customAfter this time, quench the mixture with H2O
  3. filtrationfilter the salts
  4. concentrationConcentrate the filtrate

출처 및 근거

ORD 기록
ord-936c3c50aef24950848ed4c0bb4bc33b
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851526

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