2-Chloroethanol → N-Ethyl-N-(2-hydroxyethyl)-N-[2-(4-methylphenoxy)ethyl]-amine

HRID 232313

반응식

HRID 232313 반응식
Cl[CH2:2][CH2:3][OH:4].[CH2:5]([NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1)[CH3:6].C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:5]([N:7]([CH2:2][CH2:3][OH:4])[CH2:8][CH2:9][O:10][C:11]1[CH:12]=[CH:13][C:14]([CH3:17])=[CH:15][CH:16]=1)[CH3:6]

참가 물질

5

반응물 3

HCID 342-ChloroethanolHCID 11430Potassium CarbonateHCID 20031351N-Ethyl-2-(4-methylphenoxy)ethanamine

생성물 1

HCID 20031320N-Ethyl-N-(2-hydroxyethyl)-N-[2-(4-methylphenoxy)ethyl]-amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Add 0.90 g (011 mol) 2-chloroethanol to a solution of 2.0 g (0.11 mol) N-ethyl-N-[2-(4-methylphenoxy)ethyl]amine and 1.7 g (012 mol) potassium carbonate in 50 mL methanol. Stir at room temperature for 24 hr. After this time, remove the solvents in vacuo and dissolve the residue in 25 mL water. Adjust the aqueous to pH=8 with 5% sodium bicarbonate solution and extract 3×50 mL methylene chloride. Dry the combined organics over sodium sulfate and evaporate the solvent to obtain the desired product.

후처리

  1. customAfter this time, remove the solvents in vacuo
  2. dissolutiondissolve the residue in 25 mL water
  3. extractionextract 3×50 mL methylene chloride
  4. dry with materialDry the combined organics over sodium sulfate
  5. customevaporate the solvent

출처 및 근거

ORD 기록
ord-f2eb8d7c4d324159a69739c911fcf09a
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851526

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