Phosphorus oxychloride → Methyl 6-chloro-2-(2,4-difluorophenylamino)-5-fluoronicotinate

HRID 232450노트

반응식

HRID 232450 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[N:19]=[C:18](O)[C:17]([F:21])=[CH:16][C:11]=1[C:12]([O:14][CH3:15])=[O:13].P(Cl)(Cl)(Cl)(Cl)[Cl:23].P(Cl)(Cl)(Cl)=O>O>[Cl:23][C:18]1[C:17]([F:21])=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[C:10]([NH:9][C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])[N:19]=1

참가 물질

5

반응물 3

HCID 24813Phosphorus oxychlorideHCID 24819Phosphorus pentachlorideHCID 178498343Methyl 2-(2,4-difluorophenylamino)-5-fluoro-6-hydroxynicotinate

생성물 1

HCID 13849310Methyl 6-chloro-2-(2,4-difluorophenylamino)-5-fluoronicotinate수율 34.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 9.5 g of methyl 2-(2,4-difluorophenylamino)-5-fluoro-6-hydroxynicotinate, 26.5 g of phosphorus pentachloride and 46.9 g of phosphorus oxychloride was subjected to reaction at 70°-80° C. for 4 hours. Subsequently, the reaction mixture was gradually added to 285 ml of water, and the crystals thus deposited were collected by filtration and then washed with 57 ml of water. The crystals thus obtained were purified by a column chromatography [Wako Silica Gel C-200, eluant: toluene] to obtain 3.5 g (yield 34.7%) of methyl 6-chloro-2-(2,4-difluorophenylamino)-5fluoronicotinate having a melting point of 137°-139° C.

후처리

  1. customwas subjected to reaction at 70°-80° C. for 4 hours
  2. filtrationthe crystals thus deposited were collected by filtration
  3. washwashed with 57 ml of water
  4. customThe crystals thus obtained
  5. customwere purified by a column chromatography [Wako Silica Gel C-200, eluant: toluene]

출처 및 근거

ORD 기록
ord-88d69cd5f3a24bce9cbf2c51bfede129
출처 데이터셋
uspto-grants-1989_07
특허 번호
US04851535

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