Acetic Anhydride → 2-Acetyl-1,2,4-triazine-3,5(2H,4H)-dione

반응식

[O:1]=[C:2]1[NH:7][C:6](=[O:8])[CH:5]=[N:4][NH:3]1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[C:9]([N:3]1[C:2](=[O:1])[NH:7][C:6](=[O:8])[CH:5]=[N:4]1)(=[O:11])[CH3:10]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 680371,2,4-Triazine-3,5(2H,4H)-dione

생성물 1

HCID 212565952-Acetyl-1,2,4-triazine-3,5(2H,4H)-dione

반응 조건

온도: 0 °C

실험 절차

3,5-dioxo-(2H,4H)-1,2,4-triazine (48.88 g) is heated under reflux of acetic anhydride (300 ml) for 90 minutes. After cooling and concentration to dryness under vacuum, the residue is taken up in toluene (300 ml) and cooled at 0° C. for 2 hours. The white precipitate which forms is filtered off, centrifuged, and dried under vacuum at 70° C. so as to give the compound 11a (57.6 g).

후처리

temperatureAfter cooling
concentrationconcentration to dryness under vacuum
filtrationThe white precipitate which forms is filtered off
customcentrifuged, and dried under vacuum at 70° C. so as

출처 및 근거

ORD 기록: ord-f7c15039966a406e986f2d3e26834dd6
출처 데이터셋: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05591743

반응 노트

불러오는 중…